simIDM: Simulating Oncology Trials using an Illness-Death Model

Based on the illness-death model a large number of clinical trials with oncology endpoints progression-free survival (PFS) and overall survival (OS) can be simulated, see Meller, Beyersmann and Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows for random and event-driven censoring, an arbitrary number of treatment arms, staggered study entry and drop-out. Exponentially, Weibull and piecewise exponentially distributed survival times can be generated. The correlation between PFS and OS can be calculated.

Version: 0.1.0
Depends: R (≥ 3.6)
Imports: checkmate, furrr, future, mstate, parallelly, stats, survival
Suggests: coxphw, knitr, mvna, prodlim, rmarkdown, rpact, testthat (≥ 3.0.0)
Published: 2023-12-11
DOI: 10.32614/CRAN.package.simIDM
Author: Alexandra Erdmann [aut, cre], Kaspar Rufibach [aut], Holger Löwe [aut], Daniel Sabanés Bové [aut], F. Hoffmann-La Roche AG [cph, fnd], University of Ulm [cph, fnd]
Maintainer: Alexandra Erdmann <alexandra.erdmann at>
License: Apache License 2.0
NeedsCompilation: no
Language: en-US
Materials: NEWS
CRAN checks: simIDM results


Reference manual: simIDM.pdf
Vignettes: Correlation between PFS and OS
Piecewise Constant Hazards Calculations
Getting Started
Power and Type I Error Calculations


Package source: simIDM_0.1.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): simIDM_0.1.0.tgz, r-oldrel (arm64): simIDM_0.1.0.tgz, r-release (x86_64): simIDM_0.1.0.tgz, r-oldrel (x86_64): simIDM_0.1.0.tgz
Old sources: simIDM archive


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